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KMID : 1146320200080010048
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Journal of Health Technology Assessment
2020 Volume.8 No. 1 p.48 ~ p.54
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Comparative Effectiveness of Sodium Hyaluronate and Carboxymethylcellulose for Dry Eye Syndrome: A Systematic Review
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Park Ji-Jeong
Kang Min-Joo
Shin Sang-Jin
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Abstract
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Objectives: Through a systematic review, we aimed to compare the effectiveness of sodium hyaluronate (SH) eye-drops and carboxymethylcellulose (CMC) in patients with dry eye syndrome.
Methods: A comprehensive search was performed in three foreign databases (MEDLINE, Embase, and CENTRAL) and five Korean databases up to March 2019 for a systematic review. We included studies that reported tear break-up time (TBUT) or Schirmer’s test results from clinical studies that compared SH eye-drops and CMC. A meta-analysis using random-effects model was conducted to consider the heterogeneity among the studies.
Results: Nine studies (10 comparisons) across 754 subjects were selected. Among those, eight studies used randomized control trials (RCTs). The results of a meta-analysis on TBUT showed no statistically significant difference between SH eyedrops and CMC [mean difference (MD) -0.47; 95% confidence interval (CI) -1.11, 0.18], and on Schirmer’s test (MD 0.39; 95% CI -0.71, 1.49). No significant differences between the two groups were found on corneal staining score [standardized mean difference (SMD) -0.10; 95% CI -0.31, 0.12], conjunctival staining score (SMD -0.12; 95% CI -0.34, 0.11), and symptom score (SMD -0.00; 95% CI -0.18, 0.17).
Conclusion: Compared with SH and CMC eye-drops, result of this metaanalysis provides evidence that both medicines were found to have no significant differences in all major results that measure the effectiveness of clinical treatment in dry eye syndrome.
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KEYWORD
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Dry eye syndrome, Sodium hyaluronate, Carboxymethylcellulose, Systematic review
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